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December 16, 2010The Journal of Clinical Endocrinology & Metabolism

Serum Adipocyte Fatty Acid-Binding Protein Is Associated Independently with Vascular Inflammation: Analysis with18F-Fluorodeoxyglucose Positron Emission Tomography

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Why the study?

Are circulating A-FABP levels associated with vascular inflammation measured by FDG-PET in men without cardiovascular disease or diabetes?

Population

87 Korean men without previously diagnosed cardiovascular disease or diabetes

Design

Cross-sectional

Authors

HYHye Jin YooInha University SKSungeun KimIncheon Medical Center MPMan Sik ParkSungshin Women's University

Discussion

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Implication

Hypothesis-generating for A-FABP as inflammation marker in primary prevention; leaves open prospective validation and outcome prediction.

Structured PICO

Are circulating A-FABP levels associated with vascular inflammation measured by FDG-PET in men without cardiovascular disease or diabetes?

P

Population

87 Korean men without previously diagnosed cardiovascular disease or diabetes

I

Intervention

Measurement of serum adipocyte fatty acid-binding protein (A-FABP), adiponectin, and leptin levels

O

Outcome

Vascular inflammation in the carotid arterial wall, as indicated by the target to background ratio (TBR) analyzed using FDG-PETsurrogate

Serum A-FABP levels are independently associated with carotid vascular inflammation measured by FDG-PET in men without known cardiovascular disease or diabetes.

Cite This Study

Yoo et al. (2010) studied this question.

synapsesocial.com/papers/6a7235d22fdcb5703edb8b02 https://doi.org/10.1210/jc.2010-1473

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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

1Vascular Inflammation in Patients With Impaired Glucose Tolerance and Type 2 Diabetes2010 · 115 citations
2Imaging Atherosclerotic Plaque Inflammation With [ <sup>18</sup> F]-Fluorodeoxyglucose Positron Emission Tomography2002 · 1,231 citations
3Combined Adipocyte-Macrophage Fatty Acid–Binding Protein Deficiency Improves Metabolism, Atherosclerosis, and Survival in Apolipoprotein E–Deficient Mice2004 · 194 citations
4Circulating Adipocyte–Fatty Acid Binding Protein Levels Predict the Development of the Metabolic Syndrome2007 · 361 citations