In bovine heart submitochondrial particles, the relationship between ATP synthesis rate and proton motive force is independent of how the proton motive force is decreased.
Hypothesis-generating for cardiac mitochondrial bioenergetics; leaves open translation to human disease or therapy.
The rates of electron transport and of ATP synthesis have been measured in bovine heart Mg-ATP submitochondrial particles oxidising succinate under conditions of partial attenuation of the proton-motive force by malonate or FCCP. This paper reports evidence that the relationship between the rate of ATP synthesis and the magnitude of the proton motive force is independent of the mode by which the decrease of the proton motive force is achieved.
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Sorgato et al. (1985) studied this question.
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