What question did this study set out to answer?

Review the physical and chemical mechanisms by which molecular carriers and pore-forming peptides facilitate the transport of inorganic ions across thin lipid membranes.

May 1, 1972Quarterly Reviews of Biophysics

Ion transport across thin lipid membranes: a critical discussion of mechanisms in selected systems

View Full Paper

Ask AI

Bookmark

Authors

DHD.A. HaydonUniversity of Cambridge SHStephen B. HladkyMRC Laboratory of Molecular Biology

Discussion

Member takes

Implication

Mechanistic review reveals how molecular carriers and channel-forming peptides drastically elevate ion conductance across synthetic lipid bilayers, highlighting defined structural transport pathways.

Key Points

Review the physical and chemical mechanisms by which molecular carriers and pore-forming peptides facilitate the transport of inorganic ions across thin lipid membranes.
Evaluated conductance properties of synthetic lipid bilayer model systems, specifically lecithin-decane and glyceryl mono-oleate-decane membranes in 0.1 M NaCl solutions.
Analyzed transport dynamics for defined molecular structures including lipid-soluble ions, 1:1 carriers (such as valinomycin), simple pores (such as gramicidin A), and interacting pore systems.
Pure lipid bilayer membranes in 0.1 M NaCl display negligible baseline conductance of less than 10^-9 Ω^-1 cm^-2.
Incorporation of lipid-soluble carriers (valinomycin) or channel formers (gramicidin A) markedly increases membrane conductance to greater than 10^-1 Ω^-1 cm^-2, diminishing membrane electrical resistance to levels comparable to the surrounding aqueous phase.

Cite This Study

Haydon et al. (1972) studied this question.

synapsesocial.com/papers/6a7237c7febe604dd70a7e4b https://doi.org/10.1017/s0033583500000883

View Full Paper

Ask AI

Bookmark

Implication

Mechanistic review reveals how molecular carriers and channel-forming peptides drastically elevate ion conductance across synthetic lipid bilayers, highlighting defined structural transport pathways.

Ion transport across thin lipid membranes: a critical discussion of mechanisms in selected systems

Discussion

Member takes

Implication

Key Points

Cite This Study

Ion transport across thin lipid membranes: a critical discussion of mechanisms in selected systems

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider