February 18, 2015Transboundary and Emerging Diseases

Immunization of African Indigenous Pigs with Attenuated Genotype I African Swine Fever Virus OURT88/3 Induces Protection Against Challenge with Virulent Strains of Genotype I

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Why the study?

Does immunization with attenuated ASFV strain OURT88/3 protect indigenous African pigs against virulent ASFV challenge?

Structured PICO

Does immunization with attenuated ASFV strain OURT88/3 protect indigenous African pigs against virulent ASFV challenge?

Population

Indigenous breeds of pigs from the Kinshassa region in Democratic Republic of Congo

Intervention

Immunization with attenuated African swine fever virus genotype I strain OURT88/3, followed by challenge 3 weeks later with virulent genotype I strains

Comparator

Control groups of non-immune pigs challenged with virulent strains OURT88/1 or DRC 085/10

Outcome

Protection against challenge (survival)hard clinical

Immunization with the attenuated OURT88/3 strain provides partial protection to indigenous African pigs against virulent African swine fever virus challenge.

Discussion

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Implication

Caution against field use from this small animal model; leaves open vaccine optimization for ASFV in endemic regions.

Cite This Study

Mulumba-Mfumu et al. (2015) studied this question.

synapsesocial.com/papers/6a723993fe4101aa97e0cbb9 https://doi.org/10.1111/tbed.12303

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Immunization of African Indigenous Pigs with Attenuated Genotype I African Swine Fever Virus OURT88/3 Induces Protection Against Challenge with Virulent Strains of Genotype I

Structured PICO

Discussion

Implication

Cite This Study

Immunization of African Indigenous Pigs with Attenuated Genotype I African Swine Fever Virus OURT88/3 Induces Protection Against Challenge with Virulent Strains of Genotype I

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider