Why the study?
Viral attenuation in less susceptible host cells can cause extensive mutations and genomic rearrangements that reduce immunostimulatory potential in vivo, motivating efforts to establish an attenuated ASFV strain with minimal genetic alterations in a susceptible host cell line.
Key points are not available for this paper at this time.
Population
Pigs
Comparison
Immunization twice with 105 TCID50 of Arm07ΔMGF followed by challenge with the parental strain
Design
In vitro and in vivo experimental animal study
No takes yet. Share an insight, caveat, or question.
Cell adaptation attenuates ASFV but may reduce immunogenicity; leaves open optimized attenuation strategies for vaccines.
Kitamura et al. (2023) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: