Why the study?
Does a single oral dose of sinorphan alter renal hemodynamics and sodium excretion in healthy normotensive subjects?
Does a single oral dose of sinorphan alter renal hemodynamics and sodium excretion in healthy normotensive subjects?
Neutral endopeptidase inhibition with sinorphan acutely increases endogenous ANP and induces natriuresis through altered renal hemodynamics and decreased distal tubular sodium reabsorption.
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Acute natriuresis in healthy subjects does not inform practice; leaves open effects of NEP inhibition in hypertension or HF.
Schmitt et al. (1994) studied this question.
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