Why the study?
Does sinorphan compared to captopril reduce blood pressure in patients with essential hypertension?
Does sinorphan compared to captopril reduce blood pressure in patients with essential hypertension?
Simultaneous neutral endopeptidase and ACE inhibition produces a synergistic blood pressure-lowering effect in essential hypertension, whereas monotherapy with either agent had limited 24-hour efficacy in this small cohort.
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Dual NEP/ACE inhibition yields sustained 24-h BP control in essential hypertension; confirms synergistic efficacy where monotherapies fall short.
Favrat et al. (1995) studied this question.
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