July 13, 2020Biophysical ReviewsOpen Access

Stochastic allelic expression as trigger for contractile imbalance in hypertrophic cardiomyopathy

View Full Paper

Ask AI

Bookmark

Why the study?

Hypertrophic cardiomyopathy is caused by mutations in sarcomeric genes, but a pathomechanism common to all mutations remains elusive.

Design

Review

Authors

JMJudith MontagMedizinische Hochschule Hannover TKTheresia KraftMedizinische Hochschule Hannover

Discussion

Member takes

Implication

Contractile imbalance hypothesis in HCM warrants mechanistic validation; leaves open a unifying pathomechanism and should not yet change practice.

Structured PICO

Population

Patients with hypertrophic cardiomyopathy (HCM) with mutations in sarcomeric genes, specifically β-MyHC (MYH7)

This review proposes that stochastic, burst-like transcription of mutant alleles in HCM causes cell-to-cell contractile imbalance, potentially driving myocardial disarray, hypertrophy, and fibrosis.

Cite This Study

Montag et al. (2020) studied this question.

synapsesocial.com/papers/6a723ba431a3df82432a040d https://doi.org/10.1007/s12551-020-00719-z

View Full Paper

Ask AI

Bookmark

Implication

Contractile imbalance hypothesis in HCM warrants mechanistic validation; leaves open a unifying pathomechanism and should not yet change practice.

Stochastic allelic expression as trigger for contractile imbalance in hypertrophic cardiomyopathy

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Stochastic allelic expression as trigger for contractile imbalance in hypertrophic cardiomyopathy

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider