What question did this study set out to answer?

To determine whether chronic endurance exercise training is associated with altered basal muscle sympathetic nerve activity and altered responses to acute stress in healthy older adults.

September 1, 1994Journal of Applied Physiology

Endurance exercise training is associated with elevated basal sympathetic nerve activity in healthy older humans

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Why the study?

Is endurance exercise training associated with altered basal levels of muscle sympathetic nerve activity and responses to acute stress in healthy older adults?

Population

31 healthy older adults, comprising 16 older masters endurance athletes and 15 healthy normotensive…

Comparison

Endurance exercise training vs No endurance training

Design

Cross-sectional

Authors

ANAmber NgThe University of Texas at San Antonio RCRobin CallisterUniversity of Newcastle Australia DJDavid G. JohnsonDartmouth College

Discussion

Member takes

Implication

Does not support changing exercise advice in older adults; leaves open whether elevated resting MSNA in trained women affects long-term risk.

Key Points

To determine whether chronic endurance exercise training is associated with altered basal muscle sympathetic nerve activity and altered responses to acute stress in healthy older adults.
Assessed 16 older masters endurance athletes (mean age 66 ± 1 yr; 10 men, 6 women) and 15 healthy normotensive untrained controls (mean age 65 ± 1 yr; 9 men, 6 women).
Measured muscle sympathetic nerve activity (peroneal microneurography) and plasma norepinephrine at supine rest, during a cold pressor test, and during isometric handgrip exercise at 40% maximal voluntary force.
Supine resting MSNA burst frequency was higher in athletes compared to controls (43 ± 2 vs. 32 ± 3 bursts/min, P < 0.05), as was burst incidence (75 ± 4 vs. 52 ± 5 bursts/100 heartbeats, P < 0.01).
Elevation in MSNA was driven predominantly by athletic women compared to untrained women (48 ± 4 vs. 25 ± 3 bursts/min; 82 ± 3 vs. 38 ± 3 bursts/100 heartbeats, P < 0.001).
Basal plasma norepinephrine concentrations did not differ significantly between athletes and controls, though athletes exhibited a tendency toward greater MSNA and norepinephrine responses to acute stress.

Structured PICO

Is endurance exercise training associated with altered basal levels of muscle sympathetic nerve activity and responses to acute stress in healthy older adults?

Population

31 healthy older adults, comprising 16 older masters endurance athletes (mean age 66 +/- 1 yr, 10 men, 6 women) and 15 healthy normotensive untrained control subjects (mean age 65 +/- 1 yr, 9 men, 6 women).

Intervention

Endurance exercise training (status as older masters endurance athletes)

Comparator

No endurance training (untrained healthy normotensive control subjects)

Outcome

Basal levels of muscle sympathetic nerve activity (MSNA) measured via peroneal microneurography during supine restsurrogate

Vigorous regular aerobic exercise in healthy older adults is associated with elevated resting muscle sympathetic nerve activity, particularly in women.

Cite This Study

Ng et al. (1994) studied this question.

synapsesocial.com/papers/6a723bc3febe604dd70a8032 https://doi.org/10.1152/jappl.1994.77.3.1366

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Implication

Does not support changing exercise advice in older adults; leaves open whether elevated resting MSNA in trained women affects long-term risk.

Endurance exercise training is associated with elevated basal sympathetic nerve activity in healthy older humans

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Endurance exercise training is associated with elevated basal sympathetic nerve activity in healthy older humans

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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