Antibody Binding to Individual Short Consensus Repeats of Decay-Accelerating Factor Enhances Enterovirus Cell Attachment and Infectivity

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Population

In vitro cell models expressing Decay-accelerating factor (DAF) and purified soluble DAF

Comparison

Monoclonal antibody binding to alternate short… vs Absence of alternate SCR-binding antibodies

Design

Preclinical

Authors

Discussion

May caution DAF-targeted therapies or vaccines; hypothesis-generating for antibody-enhanced viral entry and requires human validation.

Population

In vitro cell models expressing Decay-accelerating factor (DAF) and purified soluble DAF

Intervention

Monoclonal antibody binding to alternate short consensus repeats (SCR) of DAF (e.g., Ab to SCR3 for Coxsackievirus A21, Ab to SCR1 for Echovirus 7)

Comparator

Absence of alternate SCR-binding antibodies

Outcome

Viral cell attachment and infectivitysurrogate

This study provides the first demonstration that antibody binding to a viral receptor (DAF) can paradoxically enhance viral infectivity.

Shafren et al. (1998) studied this question.

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