Capture and seal off all exits! Biomacromolecules are routinely microcapsulated in poly(lactic-co-glycolic acid) (PLGA) in multiple complex steps that are deleterious to the biomacromolecule. In contrast, PLGA encapsulation based on self-healing (see picture) shows high efficiency without protein damage and enables the stabilization and slow release of proteins.
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Reinhold et al. (2012) studied this question.
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