November 6, 2003Thrombosis and Haemostasis

Increased level of oxidized LDL-dependent monocytederived microparticles in acute coronary syndrome

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Population

Patients with acute coronary syndrome, patients with stable angina, and normal controls, alongside an in…

Design

Case-control

Authors

NMNoriko MatsumotoPfizer (Japan)HKHiroshi KamihataKurume University YKYutaka KimuraKansai Medical University

Discussion

Member takes

Implication

These elevations should not yet influence ACS management; hypothesis-generating for microparticle assays in risk stratification.

Structured PICO

Population

Patients with acute coronary syndrome (ACS), patients with stable angina, and normal controls, alongside an in vitro monocytic cell line (THP-1) model.

Comparator

Normal controls and patients with stable angina

Outcome

Levels of plasma soluble P-selectin, sCD40L, platelet-derived microparticles (PDMP), monocyte-derived microparticles (MDMP), and anti-oxidized LDL antibodysurrogate

Elevated monocyte-derived microparticles associated with oxidized LDL may indicate atherosclerotic progression in acute coronary syndrome.

Cite This Study

Matsumoto et al. (2003) studied this question.

synapsesocial.com/papers/6a723f8d5d37378ac1df1a63 https://doi.org/10.1160/th03-04-0247

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Increased level of oxidized LDL-dependent monocytederived microparticles in acute coronary syndrome

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Increased level of oxidized LDL-dependent monocytederived microparticles in acute coronary syndrome

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider