Endotoxin-stimulated monocytes develop a very high tissue-factor-like activity as compared to an equivalent number of monocytes in a preparation of monocyte-enriched mononuclear blood cells obtained by Ficoll-Urovision density gradient centrifugation which is not exposed to endotoxin. In monocytes which were obtained by plastic adherence from the monocyte-enriched mononuclear blood cells, the tissue factor activity was as high as in the endotoxin-stimulated monocytes.
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Hiller et al. (2009) studied this question.