Review uncovers novel catalytic roles of divergent Group IV nitrogenases in coenzyme F430 biosynthesis, highlighting unmapped enzymatic versatility across diverse metalloenzyme families.
The nitrogenase superfamily constitutes a large and diverse ensemble of two-component metalloenzymes. These systems couple the hydrolysis of ATP to the reduction of disparate substrates from diatomic gases (Mo and alternative nitrogenases) to photosynthetic pigments (protochlorophyllide and chlorophyllide oxidoreductases). Only very recently have the activities of the highly divergent and paraphyletic Group IV nitrogenases begun to be uncovered. This review highlights the first characterized member of this group, which was found to catalyze an unprecedented reaction in the coenzyme F430 biosynthetic pathway, and the catalytic potential of a superfamily that has yet to be fully explored.
No takes yet. Share an insight, caveat, or question.
Ghebreamlak et al. (2020) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: