What question did this study set out to answer?

To evaluate whether serial evaluation of systolic and diastolic cardiac function by dobutamine stress echocardiography can predict anthracycline-induced cardiotoxicity.

July 31, 2003European Journal of EchocardiographyOpen Access

Repetitive Dobutamine Stress Echocardiography for the Prediction of Anthracycline Cardiotoxicity

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Why the study?

Does repetitive dobutamine stress echocardiography predict anthracycline cardiotoxicity in patients undergoing chemotherapy?

Population

31 patients (age 57+/-13 years, 22 male) studied before anthracycline chemotherapy

Design

Cohort

Follow-up

6 months after chemotherapy

Authors

MBManolis BountioukosUniversity of Western Macedonia

Discussion

Member takes

Implication

Baseline E/A ratio may identify anthracycline cardiotoxicity risk before chemotherapy; hypothesis-generating and requires prospective validation over stress parameters.

Key Points

To evaluate whether serial evaluation of systolic and diastolic cardiac function by dobutamine stress echocardiography can predict anthracycline-induced cardiotoxicity.
Followed 31 patients (age 57±13 years, 22 male) before chemotherapy, during treatment, at completion, and 6 months post-chemotherapy.
Assessed left ventricular function using two-dimensional wall motion score index (WMSI) and Doppler echocardiography of mitral valve inflow at rest and during dobutamine stress echocardiography, with radionuclide ventriculography as the ejection fraction reference.
A reduction in ejection fraction ≥5% occurred in 17 of 31 patients (Group A) by the 6-month post-treatment follow-up.
Resting baseline early-to-late diastolic mitral inflow velocity (E/A ratio) was significantly lower in Group A than in Group B (0.91±0.2 vs 1.28±0.3, P<0.001) and was an independent predictor of cardiotoxicity.
Resting wall motion score index paralleled radionuclide ejection fraction changes over time, while contractile reserve during low-dose dobutamine stress was preserved in Group A and offered no incremental predictive value.

Structured PICO

Does repetitive dobutamine stress echocardiography predict anthracycline cardiotoxicity in patients undergoing chemotherapy?

Population

31 patients (age 57+/-13 years, 22 male) studied before anthracycline chemotherapy

Intervention

Repetitive dobutamine stress echocardiography (DSE) and resting echocardiography (2D WMSI, Doppler mitral inflow) performed before, during, at the end, and 6 months after chemotherapy

Outcome

Prediction of anthracycline cardiotoxicity (defined as a reduction of ejection fraction >=5% by radionuclide ventriculography at 6 months post-chemotherapy)surrogate

A baseline abnormal E/A ratio at rest, rather than contractile reserve during dobutamine stress echocardiography, is an independent predictor of anthracycline-induced cardiotoxicity.

Cite This Study

Manolis Bountioukos (2003) studied this question.

synapsesocial.com/papers/6a723fa0f44fa9f079dfcc0e https://doi.org/10.1016/s1525-2167(03)00017-9

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July 31, 2003European Journal of EchocardiographyOpen Access

Repetitive Dobutamine Stress Echocardiography for the Prediction of Anthracycline Cardiotoxicity

View Full Paper

Ask AI

Bookmark

Why the study?

Does repetitive dobutamine stress echocardiography predict anthracycline cardiotoxicity in patients undergoing chemotherapy?

Population

31 patients (age 57+/-13 years, 22 male) studied before anthracycline chemotherapy

Design

Cohort

Follow-up

6 months after chemotherapy

Authors

MBManolis BountioukosUniversity of Western Macedonia

Discussion

Member takes

Implication

Baseline E/A ratio may identify anthracycline cardiotoxicity risk before chemotherapy; hypothesis-generating and requires prospective validation over stress parameters.

Key Points

To evaluate whether serial evaluation of systolic and diastolic cardiac function by dobutamine stress echocardiography can predict anthracycline-induced cardiotoxicity.
Followed 31 patients (age 57±13 years, 22 male) before chemotherapy, during treatment, at completion, and 6 months post-chemotherapy.
Assessed left ventricular function using two-dimensional wall motion score index (WMSI) and Doppler echocardiography of mitral valve inflow at rest and during dobutamine stress echocardiography, with radionuclide ventriculography as the ejection fraction reference.
A reduction in ejection fraction ≥5% occurred in 17 of 31 patients (Group A) by the 6-month post-treatment follow-up.
Resting baseline early-to-late diastolic mitral inflow velocity (E/A ratio) was significantly lower in Group A than in Group B (0.91±0.2 vs 1.28±0.3, P<0.001) and was an independent predictor of cardiotoxicity.
Resting wall motion score index paralleled radionuclide ejection fraction changes over time, while contractile reserve during low-dose dobutamine stress was preserved in Group A and offered no incremental predictive value.

Structured PICO

Does repetitive dobutamine stress echocardiography predict anthracycline cardiotoxicity in patients undergoing chemotherapy?

Population

31 patients (age 57+/-13 years, 22 male) studied before anthracycline chemotherapy

Intervention

Repetitive dobutamine stress echocardiography (DSE) and resting echocardiography (2D WMSI, Doppler mitral inflow) performed before, during, at the end, and 6 months after chemotherapy

Outcome

Prediction of anthracycline cardiotoxicity (defined as a reduction of ejection fraction >=5% by radionuclide ventriculography at 6 months post-chemotherapy)surrogate

A baseline abnormal E/A ratio at rest, rather than contractile reserve during dobutamine stress echocardiography, is an independent predictor of anthracycline-induced cardiotoxicity.

Cite This Study

Manolis Bountioukos (2003) studied this question.

synapsesocial.com/papers/6a723fa0f44fa9f079dfcc0e https://doi.org/10.1016/s1525-2167(03)00017-9

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