Ring transformation and antimicrobial activity of indolyl-substituted 2(3 H )-furanones

A variety of heterocycles of synthetic and biological importance were prepared from 3-(indol-3-yl-methylene)-5-phenyl-2(3 H )-furanone ( 1 ) and its hydrazide 2 . Compounds 1 and 2 were used for the construction of pyridazin-3(4 H )-ones 4 and 6 ; 1,3,4-oxadiazoles 7 , 8 , and 10 ; and 1,2,4 - triazoles 12 , 14 , and 15 , all bearing a 3-indolyl moiety. The antimicrobial activities of the synthesized compounds were examined against six types of bacteria and two types of fungi.