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September 10, 2025Journal of Heterocyclic Chemistry

Design, Synthesis, Antimicrobial Evaluation and Molecular Docking Study of Novel Fused Pyrazole‐Based Heterocycles Featuring Nitrogen and Sulfur Heteroatoms

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Authors

KAKhadra B. AlomariAAAsmaa L. AlanzyAAAbdulrahman S. Alharbi

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Overview

Novel fused pyrazole-based heterocycles exhibit potent antimicrobial effects, suggesting sulfur-containing structures enhance activity.

Key Points

  • A series of fused pyrazole-based heterocycles showed antimicrobial activity, notably thiazolidinone derivative 12.
  • Some compounds exhibited MICs as low as 3.125 μg/mL, comparable to standard antimicrobial agents.
  • Molecular docking revealed compound 19b had the strongest binding affinity to the bacterial ribosomal protein.
  • The findings indicate that fused frameworks and sulfur groups improve bioactivity, highlighting potential for drug development.

Cite This Study

Alomari et al. (2025) studied this question.

synapsesocial.com/papers/68c1925e9b7b07f3a0617337https://doi.org/10.1002/jhet.70090
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