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April 10, 2026Journal of Heterocyclic Chemistry

Synthesis, Biological Activity, and Docking Studies of the Fused Pyrazoline and Thiazole Hybrids

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Authors

NANagma Banu Holalgod AbbasBKBalakrishna KallurayaGSGunashree Boraiah Shivanna

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Overview

Demonstrates antimicrobial activity of synthesized compounds in vitro, suggesting potential for new medications.

Key Points

  • The research aims to explore the synthesis and biological activities of thiazole-pyrazoline hybrids.
  • Designed compounds via the Claisen-Schmidt reaction and subsequent condensation.
  • Characterized synthesized compounds using FTIR, 13C-NMR, 1H-NMR, and mass spectral analysis.
  • Evaluated antimicrobial activity against various bacterial and fungal strains.
  • Conducted molecular docking studies to understand interactions and binding energies.
  • Most compounds displayed good to moderate antimicrobial activity against Escherichia coli.
  • Compounds 5i and 5k showed significant inhibitory effects against Candida albicans.
  • Compound 5g exhibited a binding energy of −11.2 Kcal/mol towards the MurB enzyme, indicating strong interaction.

Cite This Study

Abbas et al. (2026) studied this question.

synapsesocial.com/papers/69d893eb6c1944d70ce04effhttps://doi.org/10.1002/jhet.70184
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