Exploring Drug Repositioning: A Comprehensive Review Of Clinical, Regulatory, And Marketing Strategies

Drug repositioning, a widely adopted strategy, involves the exploration of new indications for investigational or already authorized medicinal products. This approach leverages clinical, regulatory, and marketing tactics to expand a drug's utility. From a clinical perspective, repositioning offers novel insights into addressing significant public health concerns through established drugs. Regulatory agencies support this strategy by streamlining marketing authorization processes, reducing data requirements, and waiving fees. For pharmaceutical companies, repositioning represents an opportunity to develop blockbuster drugs, saving both time and resources while boosting sales and profits. The integration of digital technologies has proven particularly valuable in screening vast numbers of molecules and diseases, uncovering unexpected therapy effects, and identifying candidates for repositioning, thus accelerating the discovery of new treatments. The aim of this study is to distinguish the advantages and objectives of repositioning while analyzing historical milestones and current trends within each this approach of repositioning.