Answers are grounded in this paper and cite their sources.
The Lp(a) lipoprotein from human plasma of Lp(a+) phenotype was isolated by preparative ultracentrifugation and Sepharose 2B gel filtration. The lipoprotein was found in the plasma fraction with a density of 1,05–1.12 g/ml, and had pre‐beta mobility in agarose clectrophoresis. The molecular weight was estimated by gel filtration to be 4.8–10 6 and by electron microscopy to be 5.6–10 6 . Electron micrographs of negatively stained Lp(a) lipoprotein showed a spherical structure. Electrofocusing gave an iso‐electric point of 4.9 for this lipoprotein and of 5.5 for the low density lipoproteins (LDL). In amino acid composition the Lp(a) lipoprotein differed from both LDL and high density lipoproteins (HDL), whereas in lipid composition it was similar to LDL. Both Lp(a) lipoprotein and LDL contained small amounts of sialolactosylceramide. The Lp(a) lipoprotein contained about five times more protein‐bound sialic acid than did LDL. The total lipid content of the Lp(a) lipoprotein was 1.8 mg lipid per mg protein; this is lower than the value for LDL but higher than that for HDL.
No takes yet. Share an insight, caveat, or question.
Simons et al. (1970) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: