What question did this study set out to answer?

The study aims to explore the predictive value of increased plasma atrial natriuretic peptide during exercise for sinus rhythm maintenance after cardioversion in chronic atrial fibrillation patients.

November 1, 2000Pacing and Clinical Electrophysiology

An Increase in Plasma Atrial Natriuretic Peptide Concentration During Exercise Predicts a Successful Cardioversion and Maintenance of Sinus Rhythm in Patients with Chronic Atrial Fibrillation

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Why the study?

Does an increase in plasma ANP concentration during exercise predict successful cardioversion and maintenance of sinus rhythm in patients with chronic atrial fibrillation?

Population

42 patients with chronic atrial fibrillation (mean duration 7 +/- 7 months) and a controlled ventricular rate.

Design

Cohort

Follow-up

6 months

Authors

BWBeata Wożakowska−KapłonJan Kochanowski University GOGrzegorz OpolskiElectrophysiology DKDariusz A. KosiorMinistry of Internal Affairs of the Republic of Tajikistan

Discussion

Member takes

Implication

Exercise ANP rise may predict sinus rhythm maintenance after cardioversion; leaves open its clinical utility pending prospective validation.

Key Points

The study aims to explore the predictive value of increased plasma atrial natriuretic peptide during exercise for sinus rhythm maintenance after cardioversion in chronic atrial fibrillation patients.
42 patients with chronic atrial fibrillation underwent submaximal exercise testing 24 hours prior to cardioversion.
Blood samples were collected at rest and peak exercise to measure plasma ANP concentrations.
Multivariate logistic regression analysis assessed the association between ANP increase and successful cardioversion with sinus rhythm maintenance.
35 out of 42 patients were successfully cardioverted to sinus rhythm.
The mean increase in plasma ANP during exercise was significantly higher in those who maintained sinus rhythm (17.5 +/- 7.6 pg/mL) compared to those who did not (5.8 +/- 4.5 pg/mL), P < 0.01.
An increase in ANP plasma concentration during exercise was independently associated with successful cardioversion and maintenance of sinus rhythm for 6 months.

Structured PICO

Does an increase in plasma ANP concentration during exercise predict successful cardioversion and maintenance of sinus rhythm in patients with chronic atrial fibrillation?

Population

42 patients with chronic atrial fibrillation (mean duration 7 +/- 7 months) and a controlled ventricular rate.

Intervention

Measurement of increase in plasma atrial natriuretic peptide (ANP) concentrations during submaximal exercise testing 24 hours before cardioversion.

Outcome

Successful cardioversion and maintenance of sinus rhythm over a period of 6 months.surrogate

An exercise-induced increase in plasma ANP concentration prior to cardioversion independently predicts successful restoration and 6-month maintenance of sinus rhythm in patients with chronic AF.

Cite This Study

Wożakowska−Kapłon et al. (2000) studied this question.

synapsesocial.com/papers/6a724709ac440176ef2a98f4 https://doi.org/10.1111/j.1540-8159.2000.tb07042.x

Topics

Atrial fibrillation Persistent AF management Anticoagulation in AF AF ablation outcomes

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Implication

Exercise ANP rise may predict sinus rhythm maintenance after cardioversion; leaves open its clinical utility pending prospective validation.