Why the study?
Observational studies show metabolites may be involved in autoimmune diseases, but whether these associations are causal remains unknown.
Are human blood metabolites causally associated with the development of multiple autoimmune diseases?
Population
Large-scale GWAS summary statistics for human blood metabolites and multiple autoimmune diseases
Comparison
Genetically predicted blood metabolite levels vs multiple autoimmune diseases
Design
Two-sample Mendelian randomization study
Authors
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MR implicates metabolites in AD causality; leaves open validation before therapeutic targeting.
Are human blood metabolites causally associated with the development of multiple autoimmune diseases?
This Mendelian randomization study identified specific blood metabolites causally associated with autoimmune diseases, providing novel insights into their pathogenic processes.
Yu et al. (2021) studied this question.
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