Because it is the best-characterized example of a TOL plasmid, a detailed review of the physical nature of pWW0, its catabolic enzymes, and genetic structure is provided to develop a fundamental understanding of the molecular biology of catabolic plasmids. In addition, a current model for regulation of gene expression is presented, demonstrating the versatility and complexity that is associated with this plasmid as well as the potential complexity of other plasmid-encoded catabolic systems
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Burlage et al. (1989) studied this question.