Key result
Listeria invades endothelial cells independently of typical virulence factors, inducing IL-6 and IL-8 within ~6 hours.
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The interaction of Listeria monocytogenes with human umbilical vein endothelial cells was studied. We show that L. monocytogenes invades human umbilical vein endothelial cells independently of internalin A, internalin B, internalin C, and ActA. L. monocytogenes replicates efficiently inside the cells and moves intracellularly by the induction of actin polymerization. We further show that L. monocytogenes-infection of human umbilical vein endothelial cells induces interleukin-6 and interleukin-8 expression during the first 6 h of infection. The expression of MCP-1 and the adhesion molecules VCAM-1 and ICAM-1 was not altered under the experimental conditions used here.
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Greiffenberg et al. (2006) studied Listeria monocytogenes infection. Listeria monocytogenes infection was evaluated on Invasion, intracellular growth, movement, and cytokine/adhesion molecule expression in human umbilical vein endothelial cells. Listeria monocytogenes invades endothelial cells independently of internalins A-C and ActA, inducing IL-6 and IL-8 within 6 hours without altering MCP-1, VCAM-1, or ICAM-1.
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