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May 13, 2005Journal of Cardiovascular Pharmacology

Pharmacological therapy increased the slope of the QT-RR regression line from 0.105 +/- 0.020 to 0.144 +/- 0.037 (P < 0.05) and was associated with a reduction in VF episodes, with 6 patients having no episodes during follow-up.

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Why the study?

Does pharmacological therapy with bepridil or disopyramide alter repolarization dynamics and reduce VF episodes in patients with idiopathic ventricular fibrillation?

Population

8 men with idiopathic ventricular fibrillation who had documented spontaneous episodes of VF, 7 of whom had…

Comparison

Pharmacological therapy vs Baseline (before pharmacological therapy)

Design

Case_series

Follow-up

24 to 120 months (66.0 +/- 38.5 months) after drug therapy

Authors

MSMasataka SugaoAFAkira FujikiKNKunihiro Nishida

Discussion

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Overview

Should not yet change practice in idiopathic VF; hypothesis-generating for repolarization-targeted therapy in prospective studies.

Structured PICO

Does pharmacological therapy with bepridil or disopyramide alter repolarization dynamics and reduce VF episodes in patients with idiopathic ventricular fibrillation?

P
Population
8 men (age 43.6 +/- 9.1 years) with idiopathic ventricular fibrillation (IVF) who had documented spontaneous episodes of VF (5 with Brugada type, 3 with prominent J wave in inferior leads), 7 of whom had implantable cardioverter defibrillators.
I
Intervention
Pharmacological therapy (bepridil in 5 patients, disopyramide in 3 patients)
C
Comparator
Baseline (before pharmacological therapy)
O
Outcome
Repolarization dynamics (slope of QT-RR regression line and QT intervals at specific RR intervals from 24-hour Holter ECG) and frequency of VF episodessurrogate

Pharmacological therapy with bepridil or disopyramide prolongs QT intervals at slower heart rates and may reduce the frequency of VF episodes in patients with idiopathic ventricular fibrillation.

Cite This Study

Sugao et al. (2005) studied this question.

synapsesocial.com/papers/6a72480326a7f98052de3797https://doi.org/10.1097/01.fjc.0000159660.16793.84
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