May 8, 2018International Heart JournalOpen Access

Quantitative Differentiation of LV Myocardium with and without Layer-Specific Fibrosis Using MRI in Hypertrophic Cardiomyopathy and Layer-Specific Strain TTE Analysis

View Full Paper

Ask AI

Bookmark

Why the study?

Does layer-specific peak longitudinal strain on TTE detect layer-specific myocardial fibrosis on MRI in patients with hypertrophic cardiomyopathy?

Population

18 patients with hypertrophic cardiomyopathy, mean age 58 ± 17 years, 78% male, from a single center in Japan.

Comparison

Layer-specific peak longitudinal strain and peak… vs Late gadolinium enhancement on T1-weighted…

Design

Cross-sectional

Authors

NFNobusada FunabashiTokyo Dental College Ichikawa General Hospital HTHiroyuki TakaokaChiba University KOKoya OzawaNepean Hospital

Discussion

Member takes

Implication

Layer-specific strain on TTE may aid fibrosis localization in HCM; leaves open diagnostic validation versus MRI before clinical use.

Structured PICO

Does layer-specific peak longitudinal strain on TTE detect layer-specific myocardial fibrosis on MRI in patients with hypertrophic cardiomyopathy?

Population

18 patients with hypertrophic cardiomyopathy (HCM), mean age 58 ± 17 years, 78% male, from a single center in Japan.

Intervention

Layer-specific peak longitudinal strain (PLS) and peak circumferential strain (PCS) analysis using speckle tracking transthoracic echocardiography (TTE)

Comparator

Late gadolinium enhancement on T1-weighted cardiac magnetic resonance imaging (MRI) as the reference standard for fibrosis

Outcome

Detection of layer-specific (endocardial, epicardial, and whole-layer) left ventricular myocardial fibrosissurrogate

Quantitative regional peak longitudinal strain on speckle tracking echocardiography can non-invasively detect and localize layer-specific myocardial fibrosis in patients with hypertrophic cardiomyopathy.

Limitations

Non-randomized study in a single center
Small number of patients
No clinical events detected during observation
Did not evaluate inter-observer and intra-observer consistency
Spatial resolution of MRI is inferior to TTE

Cite This Study

Funabashi et al. (2018) studied this question.

synapsesocial.com/papers/6a724ad384cc45bb7be017f7 https://doi.org/10.1536/ihj.17-208

Topics

Hypertrophic cardiomyopathy Echocardiography

View Full Paper

Ask AI

Bookmark

Quantitative Differentiation of LV Myocardium with and without Layer-Specific Fibrosis Using MRI in Hypertrophic Cardiomyopathy and Layer-Specific Strain TTE Analysis

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Topics

Quantitative Differentiation of LV Myocardium with and without Layer-Specific Fibrosis Using MRI in Hypertrophic Cardiomyopathy and Layer-Specific Strain TTE Analysis

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Also Consider

Topics

Also Consider