This review highlights the cell and molecular abnormalities underlying right ventricular dysfunction in pulmonary hypertension and emphasizes the lack of specific information regarding this ventricle.
RV-specific molecular targets remain unaddressed in PH; leaves open dedicated research before guiding therapy.
Pulmonary vascular disease is accompanied by structural remodelling and dysfunction of the right ventricle. Current non-invasive studies describe the global performance of the right ventricle but do not explain the cell and molecular abnormalities which we need to understand if we are to develop therapeutic strategies to improve right ventricular function. This review attempt to summarise current opinion and in doing so emphasises the paucity of information specific to this ventricle.
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Sheila G. Haworth (2007) studied this question.
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