ChemInform Abstract: New Route to 1,4‐Oxazepane and 1,4‐Diazepane Derivatives: Synthesis from N‐Propargylamines

December 1, 2016ChemInform

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Key Points

To review novel synthetic strategies for constructing seven-membered 1,4-oxazepane and 1,4-diazepane heterocycles using N-propargylamines as versatile precursors.
Surveyed and evaluated 39 published references focused on synthetic routes to seven-membered nitrogen-containing heterocycles.
Analyzed reaction mechanisms, cyclization pathways, and precursor modifications involving N-propargylamine derivatives.
Identified robust cyclization methodologies that utilize N-propargylamines to generate functionalized 1,4-oxazepane and 1,4-diazepane core structures.
Demonstrated the utility of propargyl amine intermediates in streamlining access to biologically relevant seven-membered ring systems.

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Review summarizes synthetic routes to seven-membered heterocycles from N-propargylamines, highlighting efficient pathways for medicinal chemistry.

Review: [39 refs.

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Vessally et al. (2016) studied this question.

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