Why the study?
Does cardioplegia-cardiopulmonary bypass and MAPK inhibition alter coronary myogenic tone in human atrial myocardium?
Does cardioplegia-cardiopulmonary bypass and MAPK inhibition alter coronary myogenic tone in human atrial myocardium?
Cardioplegia-cardiopulmonary bypass reduces coronary myogenic tone, a process mediated in part by decreased activated ERK1/2 levels and increased MKP-1.
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May alter perioperative coronary vasoreactivity; leaves open translation to humans and ERK/MKP-1 targeting.
Khan et al. (2003) studied this question.
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