Why the study?
Reports of drug interactions between acenocoumarol and linezolid in patients post-cardiac surgery are very few.
Does concomitant administration of acenocoumarol and linezolid increase INR in post-cardiac surgery patients?
Does concomitant administration of acenocoumarol and linezolid increase INR in post-cardiac surgery patients?
Concomitant use of acenocoumarol and linezolid in post-cardiac surgery patients can lead to a dangerous drug interaction resulting in significantly elevated INR.
Alerts to possible acenocoumarol-linezolid interaction post-cardiac surgery; leaves open need for prospective confirmation.
Acenocoumarol is one of the most common drugs used as a part of the management of patients undergoing cardiac surgery. Linezolid, on the other hand, is an antibiotic prescribed post-operatively. Reports of any interaction between the two are very few. Here, we are presenting four case reports of patients admitted to the Cardio Thoracic and Vascular Surgery Department of a tertiary healthcare center in North East India. Drug-drug interactions can lead to long-term and life-threatening effects, and also hamper the management of patients post-operatively. Due to the limited literature, assessing such interactions is difficult. The cases reported here were treated with fresh frozen plasma, and the patients responded well to the treatment and were discharged without further complications.
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Sarma et al. (2024) studied this question.
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