February 1, 2006Biochemistry (Moscow)

Doxorubicin-induced thiol-dependent alteration of cardiac mitochondrial permeability transition and respiration

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Population

Heart mitochondria isolated from rats

Design

Preclinical

Authors

POPaulo J. OliveiraWake Forest University MSMaria S. SantosFernando Pessoa University KWKendall B. WallaceUniversity of North Texas

Discussion

Member takes

Implication

Hypothesis-generating for MPT-targeted cardioprotection in doxorubicin therapy; requires human confirmation before any clinical consideration.

Structured PICO

Population

Heart mitochondria isolated from rats

Intervention

Doxorubicin (DOX) treatment

Outcome

Mitochondrial permeability transition (MPT) induction and mitochondrial respirationsurrogate

Doxorubicin-induced mitochondrial dysfunction in the heart is mediated in part by thiol-dependent alteration of the mitochondrial permeability transition and respiration.

Cite This Study

Oliveira et al. (2006) studied this question.

synapsesocial.com/papers/6a725184abc331a85807ba3d https://doi.org/10.1134/s000629790602012x

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Implication

Hypothesis-generating for MPT-targeted cardioprotection in doxorubicin therapy; requires human confirmation before any clinical consideration.

Doxorubicin-induced thiol-dependent alteration of cardiac mitochondrial permeability transition and respiration

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Doxorubicin-induced thiol-dependent alteration of cardiac mitochondrial permeability transition and respiration

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider