Self‐Assembled Bifunctional Catalysis Induced by Metal Coordination Interactions: An Exceptionally Efficient Approach to Enantioselective Hydrophosphonylation

Cost effective: Bifunctional catalysts derived from commercially available chiral substituted binols and cinchona alkaloids with Ti(OiPr)4 by spontaneous metal–organic coordination (see picture) promote the asymmetric hydrophosphonylation of aldehydes in up to 99 % yield and greater than 99 % ee. The experimental conditions are capable of tolerating a relatively wide scope of substrates even in the presence of only 2.5 mol % of catalyst.