Stereoselective Solid‐Phase Synthesis of Cyclopentane and Cyclohexane Derivatives by Two‐Component Domino Reactions: Generation of Combinatorial Libraries

Diversomer libraries consisting of substituted cyclopentanes and cyclohexanes 3 were produced by Knoevenagel reaction of polymer-bound malonate 1 and aldehydes 2, subsequent ene reaction, and cleavage from the support. In this domino solid-phase procedure the simple and induced diastereoselectivities of the ene reaction are generally very satisfactory (>99:1). R = H, Me, nBu, Ph.