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Narrative review reveals widespread circadian dysfunction across neurological conditions, indicating that aligning therapeutic timing optimizes clinical patient outcomes.
OBJECTIVE: Circadian rhythms describe the near 24-hour oscillations observed across almost all biological processes on Earth. These rhythms serve to coordinate our behavior and physiology with the 24-hour light-dark environment in which we live. This article highlights normal circadian physiology and the disorders that can develop when those processes are disrupted. LATEST DEVELOPMENTS: Although historically circadian dysfunction has been viewed in terms of sleep-wake disorders, there is growing recognition that circadian disruption can contribute to or result from many other disorders frequently encountered within neurology. ESSENTIAL POINTS: When caring for patients, it is important to recognize time as a variable in disease presentation and as a potential treatment that can be harnessed to optimize patient outcomes.
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Abbott et al. (2026) studied this question.
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