January 1, 1998American Journal of Nephrology

Low Molecular Weight Heparin Reduces Triglyceride, VLDL and Cholesterol/HDL Levels in Hyperlipidemic Diabetic Patients on Hemodialysis

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Why the study?

Does low molecular weight heparin improve lipid profiles in hyperlipidemic diabetic patients on hemodialysis compared to unfractionated heparin?

Population

20 Taiwanese patients on chronic hemodialysis, comprising 10 nondiabetic patients and 10 type II diabetic…

Comparison

Fraxiparine for 6 months. vs Unfractionated heparin.

Design

Cohort

Follow-up

12 months (6 months LMWH, 6 months UF heparin)

Authors

CYChih‐Wei YangNational Taiwan University TWTsung‐Han WuNational Yang Ming Chiao Tung University CHChiu‐Ching HuangChina Medical University

Discussion

Member takes

Implication

LMWH was associated with improved lipids in diabetic HD patients; leaves open whether to switch from unfractionated heparin pending RCTs.

Structured PICO

Does low molecular weight heparin improve lipid profiles in hyperlipidemic diabetic patients on hemodialysis compared to unfractionated heparin?

Population

20 Taiwanese patients on chronic hemodialysis, comprising 10 nondiabetic patients and 10 type II diabetic patients with poor blood sugar control and hyperlipidemia (triglycerides 430.4 +/- 101.1 mg/dl, total cholesterol 219.2 +/- 12.7 mg/dl) previously on unfractionated heparin for >1 year.

Intervention

Fraxiparine (low molecular weight heparin) for 6 months.

Comparator

Unfractionated heparin (patients were switched back to unfractionated heparin for 6 months after the LMWH phase).

Outcome

Lipid profiles (triglyceride, VLDL, total cholesterol/HDL ratio) measured every 2 months.surrogate

Switching from unfractionated heparin to low molecular weight heparin for hemodialysis anticoagulation significantly reduces triglyceride and VLDL levels in hyperlipidemic diabetic patients.

Cite This Study

Yang et al. (1998) studied this question.

synapsesocial.com/papers/6a7253c175498292b70b765b https://doi.org/10.1159/000013381

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Low Molecular Weight Heparin Reduces Triglyceride, VLDL and Cholesterol/HDL Levels in Hyperlipidemic Diabetic Patients on Hemodialysis

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Low Molecular Weight Heparin Reduces Triglyceride, VLDL and Cholesterol/HDL Levels in Hyperlipidemic Diabetic Patients on Hemodialysis

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider