January 1, 1995Thrombosis and Haemostasis
Influence of Various Heparin Preparations on Lipoproteins in Hemodialysis Patients: A Multicentre Study
Why the study?
Does low molecular weight heparin improve lipid metabolism compared to unfractionated heparin in patients on chronic hemodialysis?
Population
306 patients on chronic hemodialysis, matched for sex, age and diabetes mellitus
Comparison
Low molecular weight heparin for six months or… vs Unfractionated heparin for six months or longer
Design
Cross-sectional
Authors
Discussion
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Implication
LMWH was associated with lower HDL than UFH in hemodialysis; hypothesis-generating and requires prospective confirmation before any practice implications.
Structured PICO
Does low molecular weight heparin improve lipid metabolism compared to unfractionated heparin in patients on chronic hemodialysis?
P
Population
306 patients on chronic hemodialysis, matched for sex, age and diabetes mellitus
I
Intervention
Low molecular weight heparin (LMWH) for six months or longer (mean 14.9 months)
C
Comparator
Unfractionated heparin (UFH) for six months or longer (mean 23.4 months)
O
Outcome
Lipid metabolism markers including total cholesterol, LDL cholesterol, triglycerides, apoB, apoA-IV, Lp(a), HDL cholesterol, and apoA-Isurrogate
In chronic hemodialysis patients, LMWH does not provide a beneficial effect on lipid metabolism compared to UFH, challenging previous assumptions.
Cite This Study
Kronenberg et al. (1995) studied this question.