Key result
Low molecular weight heparin was associated with a lower risk of dyslipidemia, including significantly lower triglycerides and higher HDL cholesterol during hemodialysis, compared to high molecular weight heparin.
Why the study?
Cardiovascular disease mortality is elevated in haemodialysis patients, but the comparative effects of low molecular weight heparin versus high molecular weight heparin on lipid profile remained to be evaluated.
Does low molecular weight heparin improve lipid profiles and lipoprotein lipase activity compared to high molecular weight heparin in haemodialysis patients?
Population
60 patients on haemodialysis from two main hospitals in Lahore, Pakistan
Comparison
LMWH vs HMWH
Authors
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Small HD cohort suggests possible lipid differences by heparin type; leaves open need for randomized confirmation before any practice change.
Observational (n=60)
Yes
Does low molecular weight heparin improve lipid profiles and lipoprotein lipase activity compared to high molecular weight heparin in haemodialysis patients?
p-value: p=<0.05
Low molecular weight heparin is associated with a more favorable acute lipid profile and lipoprotein lipase activity during haemodialysis compared to unfractionated heparin.
Jan et al. (2021) conducted an observational in End-stage renal disease on haemodialysis (n=60). Low molecular weight heparin (LMWH) vs. High molecular weight heparin (HMWH) / Unfractionated heparin (UFH) was evaluated on Lipoprotein lipase (LPL) activity and lipid profile changes (total cholesterol, triglycerides, HDL, LDL) (p=<0.05). Low molecular weight heparin was associated with a lower risk of dyslipidemia, including significantly lower triglycerides and higher HDL cholesterol during hemodialysis, compared to high molecular weight heparin.
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