June 13, 2013Human Reproduction Update
Antithrombotic therapy for pregnancy loss
Why the study?
Does antithrombotic therapy increase the chance of live birth in women with pregnancy loss?
Population
Women with pregnancy loss
Design
Review
Authors
Discussion
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Member takes
Implication
Antithrombotic therapy should not be used for unexplained recurrent miscarriage; leaves open its role in antiphospholipid syndrome pending larger trials.
Structured PICO
Does antithrombotic therapy increase the chance of live birth in women with pregnancy loss?
P
Population
Women with pregnancy loss (with or without thrombophilia, including antiphospholipid syndrome and inherited thrombophilia)
I
Intervention
Antithrombotic therapy
O
Outcome
Live birthhard clinical
Antithrombotic therapy is not effective for unexplained recurrent miscarriage, and more robust trials are needed to determine its efficacy in thrombophilia-associated pregnancy loss.
Limitations
- Large gaps in knowledge
- Lack of evidence
- Small-sized trials for antiphospholipid syndrome
Cite This Study
Jong et al. (2013) studied this question.