Answers are grounded in this paper and cite their sources.
2-[2H]Benzothiazole, readily available according to the literature, was observed to undergo slow isotope exchange in water. This necessitated development of practical syntheses for benzothiazoles carrying deuterium lables in positions other than 2 [4,5,6,7-2H4]Benzothiazole and 4-[2H3]methyl[5,6,7-2H3]benzothiazole were prepared in good yield from [2H7]aniline and 2-[2H9]toluidine, which were obtained by novel rapid isotope exchange in supercritical deuterium oxide.
No takes yet. Share an insight, caveat, or question.
Junk et al. (1997) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: