What question did this study set out to answer?

To investigate whether altered fasting and glucose-stimulated serum ghrelin levels contribute to sustained weight loss following gastric bypass surgery.

August 1, 2003Obesity ResearchOpen Access

Serum Ghrelin Levels in Response to Glucose Load in Obese Subjects Post‐Gastric Bypass Surgery

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Authors

NTNicholas A. TritosHarvard University EMEdward C. MunKaiser Permanente ABAnne BertkauNew York University

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Implication

Comparative study reveals suppressed serum ghrelin responses in post-gastric bypass patients, indicating chronically blunted hunger signals support sustained weight loss.

Key Points

To investigate whether altered fasting and glucose-stimulated serum ghrelin levels contribute to sustained weight loss following gastric bypass surgery.
Measured serum ghrelin concentrations during a 75-g oral glucose tolerance test (OGTT) across four groups: post-gastric bypass patients (n=6; 1.5 ± 0.7 years post-surgery), pre-gastric bypass obese patients (n=6), BMI-matched nonsurgical obese subjects (n=6), and lean controls (n=5).
Fasting serum ghrelin was significantly lower in post-bypass patients than in lean controls (by 57%) or pre-bypass obese subjects (by 45%).
Serum ghrelin levels during the OGTT were significantly lower in post-bypass patients compared to lean, pre-bypass obese, and nonsurgical obese subjects.
The post-OGTT ghrelin decline between 0 and 120 minutes was significantly smaller in post-bypass (by 62%), pre-bypass obese (by 80%), and nonsurgical obese (by 69%) groups relative to lean controls.

Cite This Study

Tritos et al. (2003) studied this question.

synapsesocial.com/papers/6a7256d75d37378ac1df2837 https://doi.org/10.1038/oby.2003.126

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Implication

Comparative study reveals suppressed serum ghrelin responses in post-gastric bypass patients, indicating chronically blunted hunger signals support sustained weight loss.

Serum Ghrelin Levels in Response to Glucose Load in Obese Subjects Post‐Gastric Bypass Surgery

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Implication

Key Points

Cite This Study

Serum Ghrelin Levels in Response to Glucose Load in Obese Subjects Post‐Gastric Bypass Surgery

Discussion

Member takes

Implication

Key Points

Cite This Study

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