Are Neutrophil/Lymphocyte Ratio, Lymphocyte/Platelet Ratio, and Ferritin Associated With Insulin Resistance in Obese With Normal Acute Phase Indicators

Introduction: Obesity is a pro-inflammatory process that stimulates the release of inflammatory mediators. The aim of study is to investigate the relationship between insulin resistance and inflammation indicators of obesity, which are not often used in practice, in patients with excess weight. Methods: We conducted a cross-sectional study on 150 patients aged 18 years and older, whose acute phase values were within normal range and were admitted to the Internal Medicine Clinic due to excess weight. We divided the participants into four groups (G1, G2, G3, G4) based on obesity and insulin resistance (HOMA-IR), and analyzed inflammatory markers such as neutrophil lymphocyte ratio (NLR), lymphocyte platelet ratio (LPO) and ferritin. Results: The results showed that all chronic diseases were more common in the G4 group. In particular, there was a significant difference (p<0.05) in the association between HT and hypothyroidism. Weight gain led to an increase in HOMA-IR (3.9±2.2), Ferritin levels (32; range 3-225), and NLO (1.8). Conclusion: This could serve as an inflammation indicator for the transition from obesity to chronic diseases.