Key result
Obesity was associated with significantly higher C-reactive protein levels compared to normal body mass index (6.21 vs 4.07, p < 0.001), with no significant differences in NLR or PLR.
Why the study?
Obesity has been recognized as a chronic low-grade inflammation condition, prompting evaluation of the predictive values of insulin resistance and inflammatory indices in individuals with obesity.
Are inflammatory markers elevated in individuals with obesity compared to those with normal body mass index?
Cross-Sectional (n=224)
No
Are inflammatory markers elevated in individuals with obesity compared to those with normal body mass index?
Absolute Event Rate: 6.21% vs 4.07%
p-value: p=<0.001
Obesity is associated with elevated CRP levels, supporting its role as a chronic low-grade inflammatory condition, though NLR and PLR were not significantly altered.
Obesity may reflect low-grade inflammation via higher CRP; cross-sectional data leave causality and clinical impact open.
Objective: Obesity has recently been recognized as a chronic low-grade inflammation condition. We aimed to compare the predictive values of insulin resistance and inflammatory indices in individuals with obesity. Materials and Methods: 124 people who had a health check for obesity-related risk factors in our hospital between June 2018 and September 2019 were included in the study. Inflammatory markers of the patients were evaluated. Results: The study group consists of a total of 224 people, and we compared the demographic data and laboratory parameters of the individuals. C-reactive protein (CRP) levels of obese individuals were statistically higher than those with normal body mass index (p <0.001). There was no statistically significant difference between the groups in terms of neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) values, among other inflammation markers. A positive and statistically significant correlation was found between body mass index and CRP level (r = 0.334, p <0.001). There was no significant correlation between body mass index and NLR and PLR. Conclusion: As a result, CRP levels of obese individuals were statistically higher than individuals with normal body mass index. No statistically significant difference was found between the groups in terms of NLR and PLR values among other inflammation markers.
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Atlı et al. (2021) conducted a cross-sectional in Obesity (n=224). Obesity vs. Normal body mass index was evaluated on C-reactive protein (CRP) levels (p=<0.001). Obesity was associated with significantly higher C-reactive protein levels compared to normal body mass index (6.21 vs 4.07, p < 0.001), with no significant differences in NLR or PLR.
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