What question did this study set out to answer?

To determine the role and regulatory mechanisms of exogenous granulocyte-macrophage colony-stimulating factor (GM-CSF) in early ovarian follicular development in immature female rats.

June 15, 2005Human ReproductionOpen Access

Exogenous granulocyte–macrophage colony-stimulating factor promotes follicular development in the newborn rat in vivo

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Authors

HWHongbo WangWeifang Medical University YWYan WenWuhan University MPMary Lake PolanLeidos (United States)

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Implication

Experimental study demonstrates that GM-CSF stimulates preantral follicle growth in immature rats, indicating an essential paracrine role in ovarian maturation.

Key Points

To determine the role and regulatory mechanisms of exogenous granulocyte-macrophage colony-stimulating factor (GM-CSF) in early ovarian follicular development in immature female rats.
Administered GM-CSF, FSH, or saline control to immature female rats for 5 or 10 days, followed by ovarian histologic evaluation and immunostaining for CYP17 and CD45.
Cultured isolated rat theca-interstitial cells with escalating concentrations of GM-CSF to measure CYP17 mRNA and protein expression in vitro.
Daily GM-CSF administration for 10 days significantly increased numbers of small preantral and large preantral follicles compared with control (P < 0.05), achieving effects similar to FSH (P < 0.05).
GM-CSF significantly upregulated CYP17 expression in theca-interstitial cells both in vivo and in vitro, whereas ovarian CD45-positive leukocyte distribution remained unchanged across all groups.

Cite This Study

Wang et al. (2005) studied this question.

synapsesocial.com/papers/6a725890e5469ee92be25ff4 https://doi.org/10.1093/humrep/dei123

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Implication

Experimental study demonstrates that GM-CSF stimulates preantral follicle growth in immature rats, indicating an essential paracrine role in ovarian maturation.

Exogenous granulocyte–macrophage colony-stimulating factor promotes follicular development in the newborn rat in vivo

Discussion

Member takes

Implication

Key Points

Cite This Study

Exogenous granulocyte–macrophage colony-stimulating factor promotes follicular development in the newborn rat in vivo

Discussion

Member takes

Implication

Key Points

Cite This Study

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