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May inform mechanistic research on chloride channels in cardiovascular disease; leaves open therapeutic targeting without clinical trials.
The review describes molecular and functional properties of the volume regulated anion channel and Ca(2+)-dependent Cl(-) channels belonging to the anoctamin family with emphasis on physiological importance of these channels in regulation of cell volume, cell migration, cell proliferation, and programmed cell death. Finally, we discuss the role of Cl(-) channels in various diseases.
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Hoffmann et al. (2014) studied this question.
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