Why the study?
Does the burden of systemic cerebrovascular risk factors differ between older psychiatric inpatients with major depression and normal controls?
Population
130 psychiatric inpatients with major depression and 64 normal control (NC) subjects, all age >= 50 years
Comparison
Burden of systemic cerebrovascular risk factors vs Normal control subjects
Design
Case-control
Authors
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No difference in cumulative CVRF scores; challenges linear small-vessel disease model for most late-life inpatient depression and leaves open AF's independent association.
Does the burden of systemic cerebrovascular risk factors differ between older psychiatric inpatients with major depression and normal controls?
The study does not support a linear model of small-vessel disease as the primary etiology for the majority of older inpatients with major depression.
Lyness et al. (1998) studied this question.
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