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November 24, 2003Journal of Paediatrics and Child Health

Pulmonary function and scoliosis in children with spinal muscular atrophy types II and III

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Why the study?

Does scoliosis surgery reduce the decline in pulmonary function in children with SMA types II and III?

Population

8 children with spinal muscular atrophy types II and III born between 1983 and 1992, necessitating scoliosis…

Comparison

Scoliosis surgery vs Preoperative state (historical control)

Design

Cohort

Follow-up

mean 44 months (range 0-110 months) postoperatively

Authors

SCSeo Yi ChngYWYQ WongJHJames Hoi Po Hui

Discussion

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Overview

Scoliosis surgery may slow FVC decline in SMA II/III; leaves open need for randomized trials before changing practice.

Structured PICO

Does scoliosis surgery reduce the decline in pulmonary function in children with SMA types II and III?

P
Population
8 children with spinal muscular atrophy (SMA) types II and III (4 type II, 4 type III) born between 1983 and 1992, necessitating scoliosis surgery.
I
Intervention
Scoliosis surgery
C
Comparator
Preoperative state (historical control)
O
Outcome
Percentage predicted forced vital capacity (FVC) and Cobb anglesurrogate

Scoliosis surgery in children with SMA types II and III may slow but does not halt the progressive decline in pulmonary function.

Cite This Study

Chng et al. (2003) studied this question.

synapsesocial.com/papers/6a725ba7f44fa9f079dfe017https://doi.org/10.1046/j.1440-1754.2003.00266.x
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Muscle Disorders in Childhood, 2nd Ed.1996 · 79 citations
  2. 2Pulmonary mechanics in patients with respiratory muscle weakness.1977 · 214 citations
  3. 3Pulmonary manifestations of neuromuscular disease with special reference to Duchenne muscular dystrophy and spinal muscular atrophy2000 · 223 citations
  4. 4Surgical Treatment of Scoliosis in a Spinal Muscular Atrophy Population1990 · 75 citations