Clinical Evaluation and Comparison of Human Chorion Membrane and Platelet-Rich Fibrin with Coronally Advanced Flap in Miller's Class I and II Recession: A Randomized Split-Mouth Clinical Trial

Background and Aim: Gingival recession is a malicious and complex phenomenon that needs to be corrected as a patient may complain of hypersensitivity, pain, increased caries risk, and compromised esthetic. Coronally advanced flap (CAF) is a successful technique for its ease of performing and predictable outcome. Guided tissue regeneration membrane such as platelet-rich fibrin (PRF) and human chorion membrane (CM) enhances periodontal regeneration. Hence, this study was conducted to evaluate and compare the efficacy of human CM and PRF with CAF in Miller’s class I and II recession defect. Materials and Methods: A total of 14 patients (28 sites) with Miller’s class I and II recession defect were assigned and randomly allocated to CM group (Group I) and PRF group (Group II). Clinical parameters recorded were recession depth (RD), recession width (RW), clinical attachment level (CAL), and width of keratinized gingiva (WKG) before surgery. Recession coverage by CAF technique with either CM or PRF was done, and all parameters were again recorded after 1, 3, and 6 months of surgery. Results: Significant decreases were seen from baseline to 6 months’ follow-up in both groups regarding RD and RW. WKG was increased in both groups. However, CAL showed statistically significant improvement only in group I and nonsignificant improvement in group II (P = 0.420) at 6 months’ follow-up. Conclusion: Both the CM and PRF are effective materials in root coverage, but CM has some amount of better result and long-time stability compared to PRF.