Depression and Cardiac Function in Patients With Stable Coronary Heart Disease: Findings From the Heart and Soul Study
Why the study?
Is major depression associated with worse cardiac disease severity in outpatients with stable coronary heart disease?
Population
1020 outpatients with stable coronary heart disease (CHD)
Comparison
Current major depression vs No current major depression
Design
Cross-sectional
Authors
Discussion
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Member takes
Implication
Depression-related CV risk in stable CHD appears independent of baseline severity; supports non-cardiac pathways but leaves open causal mechanisms.
Structured PICO
Is major depression associated with worse cardiac disease severity in outpatients with stable coronary heart disease?
P
Population
1020 outpatients with stable coronary heart disease (CHD)
I
Intervention
Current (past month) major depression (assessed using the Computerized National Institute of Mental Health Diagnostic Interview Schedule)
C
Comparator
No current major depression
O
Outcome
Cardiac disease severity (including systolic dysfunction, diastolic dysfunction, exercise-induced ischemia, and cardiac wall motion abnormalities)surrogate
Depression in patients with stable CHD is not associated with worse baseline cardiac disease severity, suggesting that the increased cardiovascular risk in depressed patients is not simply confounded by worse baseline cardiac function.
Cite This Study
Lett et al. (2008) studied this question.