Why the study?
Does profound hypothermia improve neurological outcome compared to deep hypothermia in dogs undergoing 2 hours of circulatory arrest?
Population
8 dogs undergoing cardiopulmonary bypass and 2 hours of circulatory arrest
Comparison
Profound hypothermia (PH) to 6-7 degrees C vs Deep hypothermia (DH) to 18-20 degrees C
Design
Preclinical
Authors
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Profound hypothermia merits further preclinical testing in arrest models; leaves open translation to human cardiac surgery.
Does profound hypothermia improve neurological outcome compared to deep hypothermia in dogs undergoing 2 hours of circulatory arrest?
Profound hypothermia (6-7°C) improves neurological outcomes compared to deep hypothermia in a canine model of prolonged circulatory arrest, with EEG serving as a useful predictor of recovery.
Arroyo et al. (1993) studied this question.
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