This review highlights the critical role of the subfornical organ and paraventricular nucleus in mediating the autonomic and neuroendocrine effects of circulating angiotensin II.
Identifies SFO-PVN as key CNS circuit for circulating angiotensin II; leaves open whether targeting it alters cardiovascular outcomes.
Considerable recent work has focused on identifying the mechanisms through which circulating angiotensin II acts in the central nervous system (CNS) to control a variety of different autonomic and neuroendocrine effectors. The following review will focus on work identifying the subfornical organ (SFO), and its efferent projections to the paraventricular nucleus of the hypothalamus (PVN), as a critical component of the CNS circuitry activated by circulating angiotensin II. It will also summarize the current knowledge describing cellular mechanisms through which this peptide controls the excitability of both SFO and PVN neurons.
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Alastair V. Ferguson (2009) studied this question.
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